A list of our publications can also be found on PubMed or ORCID.

Research Articles
Review Articles, Editorials/Perspectives and Book Chapters

Research Articles

“Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors”
F. Zhou, A.M. Tichy, B.N. Imambocus, F.J. Rodriguez Jimenez, M.G. Martínez, I. Jahan, M. Habib, N. Wilhelmy, V. Bräuler, T. Lömker, K. Sauter, C. Helfrich-Förster, J. Pielage, I.C. Grunwald Kadow, H. Janovjak & P. Soba
Submitted (preprint:

“Modular light-emitting diode shelving systems for scalable optogenetics”
C.G. Gangemi & H. Janovjak
Submitted (preprint:

“A F420-dependent single domain chemogenetic tool for protein de-dimerization”
J. Antoney, S. Kainrath, F.H. Ahmed, S.W. Kang, E.R.R. Mackie, T.P.S. da Costa, C.J. Jackson & H. Janovjak
Submitted (preprint:

“CDK6 activity in a recurring convergent kinase network motif”
C.G. Gangemi, R.T. Sabapathy & H. Janovjak
FASEB Journal (2023) 37: e22845

“Structure-guided optimization of light-activated chimeric G-protein-coupled receptors”
A.M. Tichy, W.L. So, E.J. Gerrard & H. Janovjak
Structure (2022) 30: 1075-1087.

“A rationally and computationally designed fluorescent biosensor for D-serine”
V. Vongsouthi, J.H. Whitfield, P. Unichenko, J.A. Mitchell, B. Breithausen, O. Khersonsky, L. Kremers, H. Janovjak, H. Monai, H. Hirase, S.J. Fleishman, C. Henneberger & C.J. Jackson
ACS Sensors (2021) 6: 4193-4205.

“Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice”
T. Rauschendorfer, S. Gurri, I. Heggli, L. Maddaluno, M. Meyer, Á. Inglés-Prieto, H. Janovjak & S. Werner
Life Science Alliance (2021) 4: e202101100.

“A light-oxygen-voltage receptor integrates light and temperature”
J. Dietler, R. Schubert, T.G.A. Krafft, S. Meiler, S. Kainrath, F. Richter, K. Schweimer, M. Weyand, H. Janovjak & A. Möglich
Journal of Molecular Biology (2021) 433: 167107.

“Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease”
A. Ingles-Prieto, N. Furthmann, S.H., Crossman, A.-M. Tichy, N. Hoyer, M. Petersen, V. Zheden, J. Biebl, E. Reichhart, A. Gyoergy, D.E. Siekhaus, P. Soba, K.F. Winklhofer & H. Janovjak
PLoS Genetics (2021) 17(4): e1009497.

“Formation of Kiss1R/GPER heterocomplex negatively regulates the Kiss1R-mediated signalling through limiting receptor cell surface expression”
R. Ke, S.I.S. Lok, K. Singh, B.K.C. Chow, H. Janovjak & L.T.O. Lee
Journal of Molecular Biology (2021) 433: 1668433.

“LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic astroglia”
C. Henneberger, L. Bard, A. Panatier, J.P. Reynolds, O. Kopach, N.I. Medvedev, D. Minge, M.K. Herde, S. Anders, I. Kraev, J.P. Heller, S. Rama, K. Zheng, T.P. Jensen, I. Sanchez-Romero, C.J. Jackson, H. Janovjak, O.P Ottersen, E.A. Nagelhus, S.H.R. Oliet, M.G. Stewart, U.V. Nägerl & D.A. Rusakov
Neuron (2020) 108: 1-18.

“All-optical miniaturized co-culture assay of voltage-gated Ca2+ channels”
V. Agus & H. Janovjak
Methods in Molecular Biology (2020) 2173: 247-260.

“Design and application of light-regulated receptor tyrosine kinases”
S. Kainrath & H. Janovjak
Methods in Molecular Biology (2020) 2173: 233-246.

“Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation”
M. Letellier, M. Lagardère, B. Tessier, H. Janovjak & O. Thoumine
eLife (2020) 9: e52027.

“Engineering strategy and vector library for the rapid generation of modular light-controlled protein-protein interactions”
A.-M. Tichy, E.J. Gerrard, J.M.D. Legrand, R.M. Hobbs & H. Janovjak
Journal of Molecular Biology (2019) 431: 3046-3055.

“Light-activated Frizzled7 reveals a permissive role of non-canonical Wnt signaling in mesendoderm cell migration”
D. Capek, M. Smutny, A.-M. Tichy, M. Morri, H. Janovjak & C.P. Heisenberg
eLife (2019) 8: e42093.

“Isolation of synaptic vesicles from genetically engineered cultured neurons”
C. McKenzie, M. Spanova, A. Johnson, S. Kainrath, V. Zheden, H.H. Sitte & H. Janovjak
Journal of Neuroscience Methods (2019) 312: 114-121.

“Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS”
W.H. Zhang, M.K. Herde, J.A . Mitchell, J.H. Whitfield, A.B. Wulff, V. Vongsouthi, I. Sanchez-Romero, P.E. Gulakova, D. Minge, B. Breithausen, S. Schoch, H. Janovjak, C.J. Jackson & C. Henneberger
Nature Chemical Biology (2018) 9: 861-869.

“Optical functionalization of human Class A orphan G-protein coupled receptors”
M. Morri, I. Sanchez-Romero, A.M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz & H. Janovjak
Nature Communications (2018) 9: 1950.

“Green light-induced inactivation of receptor signaling using cobalamin-binding domains”
S. Kainrath, M. Stadler, E. Reichhart, M. Distel & H. Janovjak
Angewandte Chemie Int. Ed. (2017) 56: 4608-4611.

“Rangefinder: A semisynthetic FRET sensor design algorithm”
J.A. Mitchell, J.H. Whitfield, W.H. Zhang, C. Henneberger, H. Janovjak, M.L. O’Mara & C.J. Jackson
ACS Sensors (2017) 1: 1286-1290.

“Method for developing optical sensors using a synthetic dye-fluorescent protein FRET pair and computational modeling and assessment”
J.A. Mitchell, W.H. Zhang, M.K. Herde, C. Henneberger, H. Janovjak, M.L. O’Mara & C.J. Jackson
Methods in Molecular Biology (2017) 1596: 89-99.

“Ancestral protein reconstruction and circular permutation for improving the stability and dynamic range of FRET sensors”
B.E. Clifton, J.H. Whitfield, I. Sanchez-Romero, M.K. Herde, C. Henneberger, H. Janovjak & C.J. Jackson
Methods in Molecular Biology (2017) 1596: 71-87.

“Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation”
K. Sako, S.J. Pradhan, V. Barone, A. Ingles‐Prieto, K.W. Rogers, P. Müller, V. Ruprecht, D. Capek, S. Galande, H. Janovjak & C.P. Heisenberg
Cell Reports (2016) 16: 866-877.

“A phytochrome sensory domain permits receptor activation by red light”
E. Reichhart, A. Ingles-Prieto, A.M. Tichy, C. McKenzie & H. Janovjak
Angewandte Chemie Int. Ed. (2016) 55: 6339-6342.

“Light-assisted small molecule screening against protein kinases”
A. Ingles-Prieto, E. Reichhart, M.K. Muellner, M. Nowak, S.M. Nijman, M. Grusch & H. Janovjak
Nature Chemical Biology (2015) 11: 952-954.

“Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction”
J.H. Whitfield, W. Zhang, M.K. Herde, B.E. Clifton, J. Radziejewski, H. Janovjak, C. Henneberger & C.J. Jackson
Protein Science (2015) 24: 1412-1422.

“Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in mammalian model cells by CE with LED-induced fluorescence detection”
J. Hühner, A. Ingles-Prieto, C. Neusüss, M. Lämmerhofer & H. Janovjak
Electrophoresis (2015) 36: 518-525.

“Spatio-temporally precise activation of engineered receptor tyrosine kinases by light”
M. Grusch*, K. Schelch*, R. Riedler*, E. Reichhart, C. Differ, W. Berger, A. Ingles-Prieto & H. Janovjak
EMBO Journal (2014) 33: 1713-1726. (* equal contribution)

“Optical control of metabotropic glutamate receptors”
J. Levitz, C. Pantoja, B. Gaub, H. Janovjak, A. Reiner, A. Hoagland, D. Schoppik, B. Kane, P. Stawski, A.F. Schier, D. Trauner & E.Y. Isacoff
Nature Neuroscience (2013) 16: 507-516.

“Optical control of ligand-gated ion channels“
S. Szobota, C. McKenzie & H. Janovjak
Methods in Molecular Biology (2013) 998: 417-435.

“A modern ionotropic glutamate receptor with a potassium-selectivity signature sequence”
H. Janovjak*, G. Sandoz* & E.Y. Isacoff
Nature Communications (2011) 2: 232. (* equal contribution)

“A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing”
H. Janovjak, S. Szobota, C. Wyart, D. Trauner & E.Y. Isacoff
Nature Neuroscience (2010) 13: 1027-1032.

“Periodic forces trigger a complex mechanical response in ubiquitin”
P. Syzmcyak & H. Janovjak
Journal of Molecular Biology (2009) 390: 443-456 (with front cover).

“Fully automated single-molecule force spectroscopy for screening applications”
J. Struckmeier, R. Wahl, M. Leuschner, J. Nunes, H. Janovjak, U. Geisler, G. Hofmann, T. Jähnke & D.J. Müller
Nanotechnology (2008) 19: 384020.

“Digital force-feedback for protein unfolding experiments using atomic force microscopy”
C.A. Bippes, H. Janovjak, A. Kedrov & D.J. Müller
Nanotechnology (2007) 18: 044022.

“Transmembrane helices have rough energy surfaces”
H. Janovjak, H. Knaus & D.J. Müller
Journal of the American Chemical Society (2007) 129: 246-247.

“Free energy of membrane protein unfolding derived from single-molecule force measurements”
J. Preiner, H. Janovjak, C. Rankl, H. Knaus, D.A. Cisneros, A. Kedrov, F. Kienberger, D.J. Müller & P. Hinterdorfer
Biophysical Journal (2007) 93: 930-937.

“Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment”
M. Cieplak, S. Filipek, H. Janovjak & K.A. Krzysko
Biochimica et Biophysica Acta (2006) 1758: 537-544 (with front cover).

“Bacteriorhodopsin folds into the membrane against an external force”
M. Kessler, K.E. Gottschalk, H. Janovjak, D.J. Müller & H.E. Gaub
Journal of Molecular Biology (2006) 357: 644-654.

“Observing folding pathways and kinetics of a single sodium-proton antiporter from E. coli
A. Kedrov, H. Janovjak, C. Ziegler, W. Kühlbrandt & D.J. Müller
Journal of Molecular Biology (2006) 355: 2-8.

“Direct measurement of single-molecule visco-elasticity in atomic force microscopy force-extension experiments”
C.A. Bippes, A.D.L. Humphris, M. Stark, D.J. Müller & H. Janovjak
European Biophysics Journal (2006) 35: 287-292.

“Complex stability of single proteins explored by forced unfolding experiments”
H. Janovjak, K.T. Sapra & D.J. Müller
Biophysical Journal (2005) 88: 37-39.

“Molecular force modulation spectroscopy revealing the dynamic response of single bacteriorhodopsins”
H. Janovjak, D.J. Müller & A.D.L. Humphris
Biophysical Journal (2005) 88: 1423-1431.

“Automated alignment and pattern recognition of single-molecule force spectroscopy data”
M. Kuhn, H. Janovjak, M. Hubain & D.J. Müller
Journal of Microscopy (2005) 218: 125-132.

“Hydrodynamic effects in fast AFM single molecule force measurements”
H. Janovjak, J. Struckmeier & D.J. Müller
European Biophysics Journal (2005) 34: 91-96.

“Probing the energy landscape of the membrane protein bacteriorhodopsin”
H. Janovjak, J. Struckmeier, M. Hubain, M. Kessler, A. Kedrov & D.J. Müller
Structure (2004) 12: 871-879 (with front cover).

“Controlled unfolding and refolding of a single sodium/proton antiporter using atomic force microscopy”
A. Kedrov, C. Ziegler, H. Janovjak, W. Kühlbrandt & D.J. Müller
Journal of Molecular Biology (2004) 340: 1143-1152.

“Unfolding pathways of native bacteriorhodopsin depend on temperature”
H. Janovjak, M. Kessler, D. Oesterhelt, H.E. Gaub & D.J. Müller
EMBO Journal (2003) 22: 5220-5229.

“Processing of gene expression data generated by quantitative real-time RT-PCR”
P.Y. Müller, H. Janovjak, A.R. Miserez & Z. Dobbie
Biotechniques (2002) 32: 1372-1380.

Review Articles, Editorials/Perspectives and Book Chapters

“Light-activated receptor tyrosine kinases: Designs and applications”
S.H. Crossman & H. Janovjak
Current Opinion Pharmacology (2022) 63: 102197.

“Optogenetic neuroregeneration”
H. Janovjak & S. Kleinlogel
Neural Regeneration Research (2022) 17: 1468-1470.

“Microbial methionine transporters and biotechnological applications”
N.A.M. Mohany, A. Totti, K.R. Naylor & H. Janovjak
Applied Microbiology and Biotechnology (2021) 105: 3919-3929.

“Synthetic sensors and signals – New tools for a new trade”
A. Möglich & H. Janovjak
Current Opinion in Structural Biology (2019) 57: iii-v.

“Light-activated chimeric GPCRs: limitations and opportunities”
A.-M. Tichy, E.J. Gerrard, P.M. Sexton & H. Janovjak
Current Opinion in Structural Biology (2019) 57: 196–203.

“Optogenetic methods in drug screening: Technologies and applications”
V. Agus & H. Janovjak
Current Opinion in Biotechnology (2017) 48: 8-14.

“Light at the end of the protein: Crystal structure of a C-terminal light-sensing domain”
H. Janovjak
Structure (2016) 24: 213-215.

“Flipping the photoswitch: Ion channels under light control“
C. McKenzie, I. Sanchez-Romero & H. Janovjak
Advances in Experimental Biology and Medicine (2015) 869: 101-117.

“The optogenetic promise for oncology: episode I”
A. Ingles-Prieto, E. Reichhart, K. Schelch, H. Janovjak & M. Grusch
Molecular and Cellular Oncology (2014) 1: e964045.

H. Janovjak & D.J. Müller
In Bioanalytik  (3rd Edition, 2012, F. Lottspeich & H. Zorbas, Editors) Spektrum Akademischer Verlag, Heidelberg.

“Structure-based design of light-controlled proteins”
H. Janovjak & E.Y. Isacoff
In Photosensitive Molecules for Controlling Biological Function (2012, J. Chambers & R.H. Kramer, Editors) Humana Press, Totowa, NJ / Springer Verlag GmbH, Heidelberg.

“Pharmacology of ionotropic glutamate receptors: A structural perspective”
P. Stawski, H. Janovjak & D. Trauner
Bioorganic & Medicinal Chemistry (2010) 18: 7759-7772 (with front cover).

“From valleys to ridges: Exploring the energy landscape of single membrane proteins”
H. Janovjak, K.T. Sapra, A. Kedrov & D.J. Müller
ChemPhysChem (2008) 9: 954-966.

“Single-molecule microscopy and force spectroscopy of membrane proteins”
A. Engel, H. Janovjak, D. Fotiadis, A. Kedrov, D. Cisneros & D.J. Müller
In Single Molecules and Nanotechnology  (Springer Series in Biophysics Vol. 12, 2008,
R. Rigler & H. Vogel, Editors) Springer Verlag GmbH, Heidelberg.

“Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy”
A. Kedrov, H. Janovjak, K.T. Sapra & D.J. Müller
Annual Review of Biophysics and Biomolecular Structure (2007) 36: 233-260.

“Imaging and detecting molecular interactions of single membrane proteins”
H. Janovjak, A. Kedrov, D. Cisneros, K.T. Sapra, J. Struckmeier & D.J. Müller
Neurobiology of Aging (2006) 27: 546-561.

H. Janovjak & D.J. Müller
In Bioanalytik  (2nd Edition, 2006, F. Lottspeich & H. Zorbas, Editors) Spektrum Akademischer Verlag, Heidelberg.

“Atomic force microscopy”
H. Janovjak, R. K. Sawhney, M. Stark & D.J. Müller
In Techniques in Microscopy for Biomedical Applications (Manuals in Biomedical Research, 2006, H. Dokland, D.W. Hutmacher & M.M. Ng, Editors)
World Scientific Publishing Company, Singapore

“Observing structure, function and assembly of single proteins by AFM”
D.J. Müller, H. Janovjak, T. Lehto, L. Kuerschner & K. Anderson
Progress in Biophysics and Molecular Biology (2002) 79: 1-43.